Cytofectins
WebFeb 15, 2002 · Anchor-dependent lipofection with non-glycerol based cytofectins containing single 2-hydroxyethyl head groups Detailed structure-activity investigations aimed at probing the anchor chain length dependency for glycerol-based lipofectins have been reported previously. WebProvided is a collection of cytofectins (cytofectins are defined as chemical species that are cationic transfection amphiphiles) or cationic lipids that bind and transport …
Cytofectins
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WebSep 28, 2008 · Finally, the compounds have been introduced into man in a gene therapy clinical trial recently initiated by Nabel etal. Because there is now a rapidly growing list of compounds that act by a similar mechanism we are referring to this class of polynucleotide delivery reagents as the “Cytofectins”. WebCompositions and methods of protecting aquatic invertebrates from disease is shown. In one embodiment, dsRNA or antisense RNA to a nucleic acid molecule of the disease-causing mic
WebHere, two homologous cationic cholesteryl cytofectins 3 beta[N-(N',N'-dimethylaminoethane)-carbamoyl] cholesterol (DC-Chol) and 3 beta[N-(N',N'-dimethylaminopropane)-carbamoyl] cholesterol (Chol-T) with 2 and 3 carbon spacer elements, respectively, have been formulated into liposomes with near equimolar … WebMar 9, 2011 · Cytotoxins. Cytotoxins are the chemical weapons that Killer T-cells use to destroy infected cells. Viruses take over healthy cells and trick them into making many …
Webionic lipids (cytofectins) have been used in many lipid-DNA formulations, and since the report of the cytofectin DOTMA2 which is often used with the neutral lipid dioleoyl L-α-phosphatidylethanolamine (DOPE) (Fig. 1), a range of related lipids have been described.1e,3 The aim in developing new cytofectins has been to optimise the delivery ... WebNov 1, 2005 · Novel N,N‘-diacyl-1,2-diaminopropyl-3-carbamoyl[bis-(2-dimethylaminoethane)] bivalent cationic lipids were synthesized and evaluated for in …
WebOct 10, 2008 · Equimolar mixtures of the new cytofectins with DOPE, which has a strong tendency to adopt an inverted hexagonal structure (H 11 phase) and which has the …
WebSep 28, 2008 · Cationic amphiphiles (cytofectins) are widely used for the transfection of cultured cells, and may become useful for the development of genetic medicines. … biologic battery testingWebTo evaluate additional delivery methods for the gene, Genzyme has an exclusive research agreement for the use of Vical's cytofectins as non-viral delivery vectors for CFTR. Also under investigation are delivery systems for the nasal epithelium using liposomes or lipid-DNA complexes. biologic basis for interleukin-1 in diseaseWebAug 1, 1999 · Cytofectin complexes. Complexes of oligonucleotides with Lipofectin® or Lipofectamine® were prepared as previously described ( 6 ), essentially according to the manufacturer's directions. Plasmid transfection assay For transfections, ECV304 or MDR3T3 cells were seeded in 6-well dishes ∼24 h prior to transfection and used at … dailymotion 4th dr whoWebCationic lipids (cytofectins) have gained widespread acceptance as pharmaceutical polynucleotide delivery agents for both cultured cell and in vivo transfection, and the cytofectins DOTAP and... biologic battery cyclerWebNational Center for Biotechnology Information biologic bike accessoriesbiologic bicycle seatWebA large number of liposome-based non-viral gene and siRNA delivery systems include monovalent cholesteryl cytofectins with acyclic head groups in their formulations. … biologic behavioral