Phosphopantetheine binding
WebUsing Escherichia coli LipB as a model enzyme, we show here that the octanoyl-transferase mainly recognizes the 4'-phosphopantetheine-tethered acyl-chain of its donor substrate and weakly binds the apo-acyl carrier protein. We demonstrate LipB can accept octanoate from its own ACP and noncognate ACPs, as well as C8-CoA. WebBinding to phosphopantetheine, the vitamin pantetheine 4'-(dihydrogen phosphate). Source: GOC:vw, GOC:mah Comment None History See term history for GO:0031177 at QuickGO …
Phosphopantetheine binding
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WebAn object of the present invention is to provide a microorganism that efficiently produces EPA and a method for producing EPA using the microorganism. The present invention relates to a microorganism having an ability to produce docosahexaenoic acid (DHA), wherein the microorganism contains a protein composed of an amino acid sequence in … WebSep 5, 2008 · The structure identifies two additional nonenzymatic domains: (i) a pseudo-ketoreductase and (ii) a peripheral pseudo-methyltransferase that is probably a remnant of an ancestral methyltransferase domain maintained in some related polyketide synthases.
WebView publication. Phosphopantetheine-binding site.: (A) Structural superposition of ATP-bound MsFadD32 and adenylate analog- and phosphopantetheine-bound PA1221 protein. The N- and C-terminal ... WebPhosphopantetheine tethering is a posttranslational modification that takes place on the active site serine of carrier proteins 138 – ‘acyl carrier proteins ... (for 4′-phosphopantetheine 10). The binding of dephospho-CoA was also shown to be competitive with both ATP and phosphopantetheine, whereas pyrophosphate was competitive with ATP ...
WebNov 9, 1999 · The first domain (AL) shows 49% similarity to long-chain fatty acid CoA-ligases and contains a putative ATP binding box. The second and fourth domains (ACP) show 45% similarity to acyl carrier proteins, and both contain a putative 4′-phosphopantetheine binding box. The third domain (KS) is 53% similar to β-ketoacyl synthetases. WebNov 13, 2013 · 4ihh: Chasing acyl carrier protein through a catalytic cycle of lipid A production.
WebJan 10, 2024 · The phosphopantetheine binding site on PCP domain (Ser702) is shown in blue. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article). 4. An asp …
WebApr 15, 1999 · The hydrogen bond between the amide of Met74 and the carboxylic oxygen at the elbow of the pantetheine arm stabilizes the bent configuration. In the free protomer, residues 72–74 hinder binding of 4′-phosphopantetheine and would result in steric conflict between Met74 and carboxylic oxygen, thus entailing backbone movement prior to binding. only my computer has slow internethttp://amigo.geneontology.org/amigo/term/GO:0031177 inward concaveWebStructural and binding studies of phosphopantetheine adenylyl transferase from Acinetobacter baumannii. Phosphopantetheine adenylyltransferase (PPAT, EC. 2.7.7.3) … only my computer no internetWebSep 4, 2024 · phosphopantetheine binding pocket, away from the solvent channel, forming a hydrogen bond with . Val73, and interacting via water molecules (not shown) with Gly71, Val74 and Asn105 (Figure 2C). only m webshopWebPhosphopantetheine-binding protein (Pectobacterium carotovorum PC1) - STRING interaction network Nodes: Network nodes represent proteins splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus. Node Color colored nodes: only my face is paleWebPhosphopantetheine-binding protein (Streptomyces rimosus subsp. rimosus ATCC 10970) Cite Download Contents 1 Sequence 2 Interactions and Pathways 3 Biochemical … only my blockWebGene Ontology Term: phosphopantetheine binding. GO ID. GO:0031177. Aspect. Molecular Function. Description. Binding to phosphopantetheine, the vitamin pantetheine 4'- … only my 2 pence